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If you happen to develop large sites in Drupal, you might fall upon a case like this one, where different servers (namely at least one reverse proxy and one web server) interact, causing a series of chain reactions every time…
This must appear in one opportunity in 1000, but it happened to me, so I bet it might have just happened to you… Munin is great, Nginx is great, and SSL is great, but when you mix all of them…
Just as a self reminder, this blog post explains why php-cgi might hang/stop silently when your load increases, and how to fix it, where it explains (in short) that fast-cgi should have the parameter PHP_FCGI_MAX_REQUESTS should equal 1000 or more…